The artistic work of Sissi starts from the desire of investigating scientific and technical themes to reach, through art, a parallel, imaginary and fantastic dimension capable of ascribing a new identity to things. Her body is the center of her research, modified through an artistic process that uses disciplines as anthropology, archaeology and anatomy to meditate on the social and cultural dynamics linked to the physical life of the body inside society. This reflection is developed through different media, from performance to installation, from photography to drawing, painting and artist’s books. Her works have been shown in numerous collective and solo exhibitions and in major galleries and museums, including Fondazione Volume, Roma; Museo del 900, Milano; Fondazione Pomodoro, Milano; 53. Biennale di Venezia; Quadriennale, Museo d'Arte Contemporanea, Zagabria, Macro, Roma; Mambo, Bologna; Turku Biennial; Chelsea Art Museum, NewYork; Brooklyn Museum, New York, Smak di Gent; MOCA, Miami; Neue Galerie am Landesmuseum Joanneum, Graz.
Winner of numerous distinguished prizes and awards, she won the Gotham Prize in 2012, the American Academy in Rome Fellowships in the Arts in 2006; the New York Prize established by the Ministry of Foreign Affairs in 2005; the Francesca Alinovi Prize for performers assigned by the Gam in Bologna in 2003. She took part to the artist-in-residence program at the Tokyo Wonder Site, Tokyo Metropolitan Foundation for History and Culture in 2008; in 2006 she won the Premio New York by The Italian Academy for Advanced Studies of the Columbia University and in 2004 she was invited as artist in residence at the Neue Galerie am Landesmuseum Joanneum in Graz. In 2002 she won the Querini Stampalia Award “Furla per l'Arte”.